Depression is a psychological disease that is increasingly common in people around the globe regardless of age. The importance of psychological health is also noticed by everyone, and it is just as important as physical health.
Many drugs and treatments for depression are given. Information about vitamin D that may be beneficial for depressed patients has also received great concern.
However, the results of the largest clinical trial ever conducted (published in JAMA) on the relationship between vitamin D and depression suggest that this important vitamin does not improve mood or prevent depression. cold.
The placebo-controlled randomized trial did not investigate subjects with pre-existing vitamin D deficiency, instead focused on the long-term effects of the supplement in other healthy subjects.
Vitamin D is made by exposing the skin to sunlight. During the overcast winter months, people can often experience a mild vitamin D deficiency. This has led some researchers to hypothesize that it plays a key role in the creation of seasonal affective disorder, a milder type of depression that occurs only in winter.
Low blood vitamin D levels are often associated with higher rates of depression, but this relationship has never been effectively determined.
Several small-scale randomized clinical trials have investigated whether vitamin D supplementation may prevent depression, or at least improve mood, in middle-aged and older subjects. Almost all trials have shown that vitamin D supplementation does not prevent depression.
This new research is being carried out as part of a larger clinical trial to explore methods to prevent cardiovascular disease and cancer. The vitamin D study group included 18,353 subjects with an average age of 67 years.
Lead author of the study, Olivia Okereke, explains: “One scientific problem is that it really takes a very large number of study participants to know if a treatment helps prevent the development of Depression or not. With nearly 20,000 people, our research has been statistic to solve this problem.
The participants were randomized into a placebo group and an active group. Among them, the active group took 2000 IU cholecalciferol (vitamin D3) daily, with a follow-up period of 5 years.
At the end of the study, the researchers said that the results were clear. There was no statistically significant difference in the rates of depression between the vitamin D and placebo groups. More importantly, there was not even a major difference in self-reported mood scores between the two groups during the long trial period.
The study only focused on subjects with a healthy baseline vitamin D level. An increase in vitamin D levels was detected in the group that did not take a placebo during the trial period. However, the scientists note that more research is needed to fully understand the potential effects of long-term, high-dose vitamin D supplementation in subjects with clinically ill, nutrient deficient subjects.
So while research may effectively suggest that healthy older adults do not need vitamin D as a preventive measure for depression, it is not yet clear whether a severe deficiency leads to depression. to mood imbalance or depression or not.
Essentially, this is another study in a developing team that says supplementing with basic vitamins is ineffective in people who are not undernourished.
The author of the article, JoAnn Manson, appropriately reminds me that this study does not encourage people to stop taking vitamin D immediately. The essential vitamins may not prevent depression, but they are important and essential for general health.
“Vitamin D is an essential nutrient for bones and metabolic health, but randomized trials have shown many other benefits of this vitamin,” Manson said.
Huong Giang (Source: New Atlas)