Diets low in fat and supplemented with fish oil reduced the progression of prostate cancer

Prostate cancer or prostate cancer today is one of the most common cancers in men. In the US, since the 1975s, the incidence of prostate cancer has been around 90 / 100,000 and the death rate from this cancer has been around 35 / 100,000 men each year. This disease is a nightmare for men, so its prevention and treatment always receives great attention.

In an analysis reported in the journal Cancer Prevention Research, Galet et al analyzed the effects of diet on men with prostate cancer.

They found that men on a low-fat diet and supplemented with fish oil had lower cell cycle growth scores and a somewhat less severe condition.

This study is a sequel to the 2011 pre-investigative Phase II randomized trial conducted by the same group of researchers. The 2011 study compared men with prostate cancer who ate the typical Western high-fat diet with those on a low-fat diet and fish oil supplements.

The fat content for those following a Western diet is 40%. In contrast, the fat content for those on low-fat diets was 15%.

Fat sources include high levels of omega-6 fatty acids from corn oil (especially linoleic acid) and low amounts of fish oil (which provide omega-3 fatty acids). The men who followed a low-fat diet and supplemented with fish oil took 5 capsules (5 g / capsule) per day, 3 capsules at breakfast and 2 capsules at dinner.

People who eat a low-fat diet and supplement with fish oil have a lower rate of prostate cancer cell cycle development, which in turn helps their doctor come up with the right treatment. (Artwork photo)

Investigators concluded from previous research that a diet low in fish oil for 4 to 6 weeks did not affect serum IGF-1 levels but decreased the ratio of omega-6 to omega-3 fatty acids. .

The current study is based on prostate serum and tissue samples from the 2011 study. The Western diet group consisted of 21 patients and the fish oil diet group had 27 patients. Most patients in both groups are characterized by being overweight or obese. Patients maintain the respective diet for a period of 28 to 30 days.

Cell cycle progression was measured from 16 patients in the Western diet group and 20 from the low-fat fish oil group. In some cases, the cell cycle progression score has been shown to be a predictor of prostate cancer recurrence.

One remarkable finding from the current study is that in men on a diet low in fish oil, the ratio of omega-6 to omega-3 fatty acids decreased. In addition, the concentration of 15-S-hydroxyeicosatetraenoic acid also decreased in this group of patients.

As for the cell cycle progression scores, it was found that patients on the fish oil diet were lower than those on the Western diet. The analyzes showed a significantly positive correlation between changes in leukotriene B4 levels and cell cycle progression scores.

“With the help of reliable cell cycle progression scores and other markers, we can predict which patient’s prostate cancer will return,” the researchers concluded. Treat according to the right method. Our research shows that, by changing our diet, we can positively impact prostate cancer biology.

Doctor William J. Aronson, UCLA Jonsson Comprehensive Cancer Center, author respectively for the article in Cancer Prevention Research.

Huong Giang (Source: ascopost)



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