Discovery of a stomach ulcer drug that prevented Covid-19 from multiplying

According to researchers from the University of Hong Kong, the drug RBC containing the active ingredient bismuth is capable of reducing the viral load in Covid-19 infected cells in humans and animals to 0.001% of the initial load. Compared to the previous administration of RBC, the Covid-19 load in the upper and lower gastrointestinal tract of the hamster decreased to 0.01%.

RBC (ranitidine bismuth citrate) is an oral pill for stomach ulcers, reflux oesophagitis, and stress-induced gastrointestinal bleeding.

The University of Hong Kong has discovered a drug that prevents Covid-19 from multiplying. Illustration

The team found that RBC has the ability to target Nsp13 proteins, an important enzyme that helps nCoV regenerate. This is the first time that scientists have revealed that Nsp13 can be targeted with drugs.

According to Dr. Runming Wang, Department of Chemistry, University of Hong Kong, as soon as Nsp13 is no longer active, nCoV will lose its ability to regenerate or multiply.

The results of the study, published in the journal Nature Microbiology on October 7, promise a new treatment option, available to Covid-19 patients.

“The RBC shows efficacy comparable to that of remdesivir, safe, and ready for use in clinical trials,” said Dr. Runming Wang.

Professor Hongzhe Sun, from the University of Hong Kong, said concerns about drug resistance are very low. RBC targets the Nsp13 proteins and they cannot mutate too much, otherwise the cells cannot survive. RBC can be administered as a combination drug targeting multiple regions, making it harder for Covid-19 to build resistance.

GS. Sun estimates that the cost of a course of Covid-19 with RBC is about $ 3,000, only 25% of the cost of a treatment with remdesivir.

Currently, the Hong Kong team has applied for a US patent to use RBC in the treatment of Covid-19 patients.

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In July, the Stem Cell Association sent the Medical Ethics Council a letter signed by 90 scientific, medical and patient organizations, calling for permission to use fetal tissue to develop Covid therapeutic drug. -19.

Fetal tissue has unique and valuable properties that cannot be replaced by other types of cells, the researchers added.

The REGN-COV2 antibody mixture uses two laboratory-developed strains, one monoclonal antibody that targets the spiny protein, and an antibody that attacks another part of Covid-19.

Monoclonal antibodies are biological therapy that uses technology to make copies of human antibodies against the virus. In the initial trial, this therapy is for people who are newly infected.

The Covid-19 pandemic is one of the greatest challenges modern medicine has ever faced. To date there are more than 39 million infected people in the world, more than 1,100,000 deaths.

Over the past 9 months, the scientific community is still looking for the optimal treatment. The most-mentioned drugs include the antiviral drug Remdesivir produced by Gilead Sciences, a drug from Japan, Favipiravir, and the cheap steroid medicine Dexamethasone …

An Duong (Th)



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