Genes can determine whether or not a fish oil supplement is healthy or good


Busy life, inadequate diet, … are the reasons why many people choose to use functional foods to enhance their health. However, the oral supplements actually support essential nutrients for the body. Fish oil is one of the many supplements that are gaining popularity, and people are concerned about its true effects.

A new study has stated that the cardiovascular benefits commonly attributed to fish oil supplementation may be apparent only in individuals of a certain genotype.

This study investigates the relationship between genetics, diet and heart health, suggesting that in the future, nutritional recommendations can be optimized by taking into account unique genetic factors. of a person.

In recent years, more and more research institutions have begun to question the popular advice that omega-3 fish oil supplements are beneficial for people at high risk of cardiovascular disease.

Several large-scale meta-analyzes have found no benefit from taking this supplement. The phase 3 clinical trial that looked at the pure concentrate of a particular fatty acid present in fish oil was discontinued after interim data did not reveal a benefit.

A new study, published in the journal PLOS Genetics, investigates whether a new genetic and dietary interaction could explain the obvious difference in the previous study.

The whole genome-linking study was performed, including more than 70,000 participants in Biobank in the UK. A specific genetic variation that affects the gene called GJB2 has been identified in the study to be significantly associated with reductions in triglycerides in subjects taking fish oil supplements.

Different genotypes can have positive or negative health effects when taken with fish oil supplements. (Artwork image)

While the AG variant was beneficial, leading to a reduction in triglycerides, another variant, called AA, was associated with higher triglyceride levels in those taking the supplement in those who took the supplement. Take fish oil supplements.

“What we found is that fish oil supplementation is not good for everyone,” said Kaixiong Ye, an assistant professor at the University of Georgia and lead author of the study. It also depends on the genotype of each person. If people have a specific genetic background, then taking fish oil supplements will help reduce triglycerides. But without the right genotype, the addition of fish oil actually increases triglycerides in the body.

Ye says that this new study may help explain why a large number of previous studies on fish oil supplementation and heart health have led to conflicting findings.

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“Previous clinical trials did not look at the participants’ genotypes. Some participants might benefit and some can’t, so if you combine them and do the analysis, people won’t see the impact, ”said Ye.

If confirmed by further studies, the type of interaction between the gene and According to diet, nutritional advice can be tailored specifically for each subject based on many different physiological factors, including genetics.

“Personalizing and optimizing recommendations for fish oil supplements based on one’s genetic makeup can provide more of our understanding of nutrition and lead to significant improvements in,” Ye concludes. human health ”.

Huong Giang (Source: New Atlas)

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